1. publications

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  1. Jennifer L. Walker, Luke H. C. Patterson, Evelyn Rodriguez-Mesa, Kevin Shields, John S. Foster, Megan T. Valentine, Adele M. Doyle, Kimberly L. Foster "Controlled Single-Cell Compression With a High-Throughput MEMS Actuator" Journal of Microelectromechanical Systems (In Press). [LINK]
  2. Luke HC Patterson, Jennifer L Walker, Mark A Naivar, Evelyn Rodriguez-Mesa, Mehran R Hoonejani, Kevin Shields, John S Foster, Adele M Doyle, Megan T Valentine, Kimberly L Foster "Inertial flow focusing: a case study in optimizing cellular trajectory through a microfluidic MEMS device for timing-critical applications" Biomedical Microdevices 22(2) 1-12 (2020). [LINK]
  3. Roopa Madhu, Delany Rodriguez, Claudia Guzik, Shambhavi Singh, Anthony W De Tomaso, Megan T Valentine, Dinah Loerke "Characterizing the cellular architecture of dynamically remodeling vascular tissue using 3-D image analysis and virtual reconstruction" Molecular Biology of the Cell 31(16), 1714-1725 (2020). [LINK]
  4. Thomas R. Cristiani, Emmanouela Filippidi, Megan T. Valentine, Claus D. Eisenbach "Tailoring the Toughness of Elastomers by Incorporating Ionic Cross-Linking" Macromolecules 53(10), 4099-4109 (2020). [LINK]
  5. Serena Seshadri, Luke F. Gockowski, Jaejun Lee, Miranda Sroda, Matthew E. Helgeson, Javier Read de Alaniz, Megan T. Valentine "Self-regulating photochemical Rayleigh-Benard convection using a highly-absorbing organic photoswitch" Nature Communications 11 2599 (2020). [LINK]
  6. Luke F. Gockowski, Neil D. Dolinski, Roberto Chavez, Noy Cohen, Fabian Eisenreich, Stefan Hecht, Robert M. McMeeking, Craig J. Hawker, and Megan T. Valentine, "Engineering crack tortuosity in printed polymer-polymer composites through ordered pores" Materials Horizons 7 1854-1860 (2020). [LINK]
  7. Bugra Kaytanli, Aimal H. Khankhel, Noy Cohen, Megan T. Valentine "Rapid analysis of cell-generated forces within a multicellular aggregate using microsphere-based traction force microscopy" Soft Matter 16 4192-4199 (2020). [LINK]
  8. Liam P. Dow, Aimal H. Khankhel, John Abram, Megan T. Valentine "3D-printable cell crowding device enables imaging of live cells in compression" BioTechniques 68(5) 4192-4199 (2020). [LINK]
  9. Luke Patterson, Jennifer Walker, Evelyn Rodriguez-Mesa, Kevin Shields, John Foster, Megan T. Valentine, Adele Doyle, and Kimberly Foster "Investigating Cellular Response to Impact With a Microfluidic MEMS Device" Journal of Micrelectromechanical Systems 29 14-24 (2020). [LINK]
  10. Noy Cohen, J. Herbert Waite, Robert M. McMeeking, Megan T. Valentine "Force distribution and multiscale mechanics in the mussel byssus" Philosophical Transactions of the Royal Society B 374 (1784) 20190202 (2019). [LINK]
  11. Luke Patterson, Jennifer Walker, Evelyn Rodriguez-Mesa, Kevin Shields, John Foster, Megan T. Valentine, Adele Doyle, and Kimberly Foster "The micro-Hammer: Investigating cellular response to impact with a high throughput microfluidic MEMS device" Proceedings of the Solid-State Sensor, Actuator, and Microsystems Workshop, Hilton Head, SC, (2018). DOI 10.31438/trf.hh2018.47
  12. Emmanouela Filippidi, Thomas R. Cristiani, Claus D. Eisenbach, J. Herbert Waite, Jacob N. Israelachvili, B. Kollbe Ahn, Megan T. Valentine "Toughening elastomers using mussel-inspired catechol-iron complexes" Science 358 (6362) 502-505 (2017). [LINK]
  13. Ilia Kaminker, Wei Wei, Alex M. Schrader, Yeshayahu Talmon, Megan T. Valentine, Jacob N. Israelachvili, J. Herbert Waite, and Songi Han "Simple peptide coacervates adapted for rapid pressure-sensitive wet adhesion" Soft Matter 13 9122-9131 (2017). [LINK]
  14. Menaka Wilhelm, Emmanouela Filippidi, J. Herbert Waite, and Megan T. Valentine, "Influence of multi-cycle loading on the structure and mechanics of marine mussel plaques" Soft Matter 13 7381-7388 (2017). [LINK]
  15. Sungbaek Seo, Dong Woog Lee, Jin Soo Ahn, Keila Cunha, Emmanouela Filippidi, Sung Won Ju, Eeseul Shin, Byeong-Su Kim, Zachary A. Levine, Roberto D. Lins, Jacob N. Israelachvili, J. Herbert Waite, Megan T. Valentine, Joan Emma Shea, and B. Kollbe Ahn "Significant performance enhancement of polymer resins by bioinspired dynamic bonding" Advanced Materials 1703026 (2017) [LINK]
  16. Delany Rodriguez, Brian P. Braden, Scott W. Boyer, Daryl A. Taketa, Leah Setar, Chris Calhoun, Alessandro Di Maio, Megan T. Valentine and Anthony W. De Tomaso "In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate" Molecular Biology of the Cell 28(14) 1883-1893 (2017). [LINK]
  17. Jamianne C. Wilcox, Benjamin J. Lopez, Otger Campas and Megan T. Valentine. "Improved calibration of the nonlinear regime of a single-beam gradient optical trap" Optics Letters 41(10) 2386-89 (2016). [LINK]
  18. Dezhi Yu, Stuart C. Feinstein, and Megan T. Valentine. "Effects of wild type tau and disease-linked tau mutations on microtubule organization and intracellular trafficking in COS-7 cells" Journal of Biomechanics 48(8) 1280-85 (2016). [LINK]
  19. Benjamin J. Lopez and Megan T. Valentine. "The +TIP coordinating protein EB1 is highly dynamic and diffusive on microtubules, sensitive to GTP analog, ionic strength, and EB1 concentration" Cytoskeleton 73(1) 23-34 (2016) [LINK]
  20. Emmanouela Filippidi, Daniel G. DeMartini, Paula Malo de Molina, Eric W. Danner, Juntae Kim, Matthew E. Helgeson, J. Herbert Waite and Megan T. Valentine. "The microscopic network structure of mussel (Mytilus) adhesive plaques" Journal of the Royal Society Interface 12(113) 20150827 (2015). [LINK]
  21. Benjamin J. Lopez and Megan T. Valentine. "Molecular control of stress transmission in the microtubule cytoskeleton" Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 3015-3024 (2015). [LINK]
  22. Kenneth W. Desmond, Nicholas A. Zacchia, J. Herbert Waite, and Megan T. Valentine. "Dynamics of Mussel Plaque Detachment" Soft Matter 11 6832-6839 (2015). [LINK]
  23. Nicholas A. Zacchia and Megan T. Valentine. "Design and optimization of arrays of neodymium iron boron-based magnets for magnetic tweezers applications" Review of Scientific Instruments 86 053704 (2015). [LINK]
  24. Christian Vaca, Roie Shlomovitz, Yali Yang, Megan T. Valentine, and Alex J. Levine. "Bond breaking dynamics in semiflexible networks under load" Soft Matter 11 6832-6839 (2015). [LINK]
  25. Benjamin J. Lopez and Megan T. Valentine. "Mechanical effects of EB1 on microtubules depend on GTP hydrolysis state and presence of paclitaxel" Cytoskeleton 71 530-541 (2014). [LINK]
  26. Dezhi Yu, Nichole E. LaPointe, Elmer Guzman, Veronica Pessino, Leslie Wilson, Stuart C. Feinstein, and Megan T. Valentine. "Tau Proteins Harboring Neurodegeneration-linked Mutations Impair Kinesin Translocation in vitro" Journal of Alzheimer's Disease 39 301-314 (2014). [LINK]
  27. Yali Yang and Megan T. Valentine. "Determining the structure-mechanics relationships of dense microtubule networks with microscopy and microrheology," Methods in Cell Biology 115 75-96 (2013). [LINK].
  28. Dezhi Yu, Veronica Pessino, Steve Kuei, and Megan T. Valentine. "Mechanical and functional properties of epothilone-stabilized microtubules," Cytoskeleton 70(2) 74-84 (2013). [LINK].
  29. Bugra Kaytanli and Megan T. Valentine. "Evolute-based Hough transform method for characterization of ellipsoids," Journal of Microscopy 249(3) 159-164 (2013). [LINK].
  30. Yali Yang, Mo Bai, William S. Klug, Alex J. Levine and Megan T. Valentine. "Microrheology of highly crosslinked microtubule networks is dominated by force-induced crosslinker unbinding," Soft Matter 9 383-393 (2013). [LINK]
  31. David Valdman, Benjamin J. Lopez, Megan T. Valentine, and Paul J. Atzberger. "Force spectroscopy of complex biopolymers with heterogeneous elasticity," Soft Matter 9 772-778 (2013). [LINK]
  32. Jun Lin and Megan T. Valentine. "High-force NdFeB-based magnetic tweezers device optimized for microrheology experiments," Review of Scientific Instruments 83 053905 (2012). [LINK]
  33. Jun Lin and Megan T. Valentine. "Ring-shaped NdFeB-based magnetic tweezers enables oscillatory microrheology measurements," Applied Physics Letters 100 201902 (2012). [LINK]
  34. David Valdman, Paul J. Atzberger, Dezhi Yu, Steve Kuei and Megan T. Valentine. "Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers," Biophysical Journal 102(5) 1144-1153 (2012). [LINK]
  35. Yali Yang*, Jun Lin*, Bugra Kaytanli, Omar Saleh and Megan T. Valentine. "Direct correlation between creep compliance and deformation in entangled and sparsely crosslinked microtubule networks," Soft Matter 8 1776-1784 (2012). [LINK]
  36. Yali Yang*, Jun Lin*, Ryan Meschewski, Erin Watson, and Megan T. Valentine. "Portable magnetic tweezers device enables visualization of the three-dimensional microscale deformation of soft biological materials," BioTechniques 51 29-34 (2011). [PDF]
  37. Megan T. Valentine and Steven M. Block. "Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers," Biophysical Journal 97 1671-7 (2009). [PUBMED]
  38. Michael T. Woodside and Megan T. Valentine . (2009) "Single-molecule manipulation using optical traps," in Handbook of Single-Molecule Biophysics, eds. Peter Hinterdorfer and Antoine Van Oijen. New York, NY: Springer.
  39. Megan T. Valentine* , Nicholas R. Guydosh*, Braulio Gutierrez-Medina*, Adrian N. Fehr*, Johan O. Andreasson*, and Steven M. Block. "Precision steering of an optical trap by electro-optic deflection," Optics Letters 33 599-601 (2008). [PUBMED]
  40. Megan T. Valentine and Susan P. Gilbert. "To Step or Not to Step? How Biochemistry and Mechanics Influence Processivity in Kinesin and Eg5," Current Opinion in Cell Biology 19 75-81 (2007). [PUBMED]
  41. Polly M. Fordyce*, Megan T. Valentine * and Steven M. Block. 2007. "Advances in surface-based assays for single molecules," in Single-Molecule Techniques: A Laboratory Manual, eds. Paul Selvin and Taekjip Ha. Woodbury, NY: Cold Spring Harbor Laboratory Press.
  42. Megan T. Valentine , Polly M. Fordyce, and Steven M. Block. "Eg5 steps it up!," Cell Division 1 31 (2006). [PUBMED]
  43. Megan T. Valentine *, Polly M. Fordyce*, Troy C. Krzysiak, Susan P. Gilbert, Steven M. Block. "Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro," Nature Cell Biology 8 470 (2006). [PUBMED]
  44. M.T. Valentine , Z.E. Perlman, T.J. Mitchison, and D.A. Weitz. "Mechanical properties of Xenopus egg cytoplasmic extracts," Biophysical Journal 88 680 (2005). [PUBMED]
  45. M.L. Gardel, M.T. Valentine , and D.A. Weitz. (2005) "Microrheology" in Microscale Diagnostic Techniques ed. K. Breuer. New York: Springer-Verlag. [PDF]
  46. M.T. Valentine , Z.E. Perlman, M.L. Gardel, J.H. Shin, P. Matsudaira, T.J. Mitchison, and D.A. Weitz. "Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials," Biophysical Journal 86 4004-14 (2004). [PUBMED]
  47. I.Y. Wong, M.L. Gardel, David R. Reichman, Eric R. Weeks, M.T. Valentine , A.R. Bausch, D.A. Weitz. "Anomalous diffusion probes microstructure dynamics of entangled F-actin networks," Physical Review Letters 92 178101 (2004). [PUBMED]
  48. M.L. Gardel, M.T. Valentine , J.C. Crocker, A.R. Bausch, and D.A. Weitz. "Microrheology of entangled F-actin solutions," Physical Review Letters 91 158302 (2003). [PUBMED]
  49. Vernita D. Gordon, M.T. Valentine , M.L. Gardel, Daniel Andor, Samantha Dennison, Alexei A. Bogdanov, D.A. Weitz, and Thomas S. Deisboeck. "Measuring the mechanical stress induced by a dynamically expanding multicellular tumor system within a three-dimensional in vitro assay," Experimental Cell Research 289 58 (2003). [PUBMED]
  50. A.K. Popp, M.T. Valentine , P.D. Kaplan, D.A. Weitz. "Microscopic origin of light scattering in tissue," Applied Optics 42 2871 (2003). [PUBMED]
  51. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz. "Microscope-based static light scattering instrument," Optics Letters 26 890 (2001). [PUBMED]
  52. M.T. Valentine , P.D. Kaplan, D. Thota, J.C. Crocker, T. Gisler, R.K. Prud'homme, M. Beck, and D.A. Weitz. "Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking," Physical Review E 64 061506 (2001). [PUBMED]
  53. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz "Microscope-based static light scattering instrument enables precise measurements of heterogeneous materials," Optics and Photonics News 12 37 (2001). [PDF] Edition highlights 200 of the most exciting new optics innovations of the year.
  54. A.K. Popp, M.T. Valentine , P.D. Kaplan, and D.A. Weitz. "Light scattering microscope as a tool to investigate scattering heterogeneity in tissue," Proceedings of the SPIE, Optical Biopsy III Conference, San Jose, CA, Robert R. Alfano, Ed. 3917 22 (2000). [PDF]
  55. John C. Crocker, M.T. Valentine , Eric R. Weeks, T. Gisler, P.D. Kaplan, A.G. Yodh, and D.A. Weitz. "Two-point microrheology of inhomogeneous soft materials," Physical Review Letters 85 888 (2000). [PUBMED]
  56. M.T. Valentine , L.E. Dewalt, and H.D. Ou-Yang. "Forces on a colloidal particle in a polymer solution: a study using optical tweezers," Journal of Physics: Condensed Matter (U.K.). 8 9477 (1996). [PDF]